• NCT04832932
  • NCT03451994
  • NCT03582826
  • NCT02692495
  • NCT02683876


  • January Case Reports
  • Reactivated Virus: 7/2/2021
  • Autoimmunity: 5/16/2021
  • Anaphylaxis: 3/20/2021
  • Genes and Proteins: 4/13/2020
  • Sniffing COVID: 6/20/2020
  • Personalized vaccines: 5/21/2020

    Other Blog Posts

  • Lipid dysregulation

    Evolution of Viruses

    Fatal breakthroughs in the omicron era

    January 21, 2022: Another case report on fatal breakthrough with brain involvement. Neurological manifestations are common in COVID-19. A sudden-onset reversible cerebral vasoconstriction syndrome (RCVS), possibly caused by a transient dysregulation of cerebral vascular tone, is described in this fatal COVID-19 vaccine breakthrough case.

    January 16, 2022: A fatal case of COVID-19 breakthrough infection in a 61-year old man A 61-year-old man with a history of arterial hypertension (PA 145/95 mmHg) and obesity with a body mass index (BMI) of 37.11 was vaccinated with a double dose of mRNA vaccine, but 4 months after the 2nd dose was diagnosed with COVID-19 and died 15 days after diagnosis despite treatment.

    January 13, 2022: Young COVID-19 vaccine breakthrough fatalities Vaccine effectiveness may fail for individuals with particular genetics and we need more studies and more medical case reports to develop personalized preventative and curative approaches.

    January 12, 2022: Post-infectious body odor A paper posted today on MedRxiv tells that dogs can easily detect long COVID - and not only acute COVID-19 - in at least half of the cases. Vaccine effectiveness may fail for individuals with particular genetics and we need more studies and more medical case reports to develop personalized preventive and curative approaches.

    January 8, 2022: Risk Factors for Severe COVID-19 Outcomes Among Vaccinated Individuals New Morbidity and Mortality Weekly Report (MMWR) emphasizes the usual risk factors for fatal breakthroughs: age 65 or older or at least one of these conditions: diabetes mellitus, immunosuppression, chronic kidney disease, chronic liver disease, chronic neurologic disease, chronic cardiac disease, or chronic pulmonary disease.

    January 6, 2022:

    There were four fatalities among 65 fully vaccinated and boosted (FV&BCOVID-19 patients at an acute-care hospital system in Southeastern Michigan. In the FV&B cohort that required ICU-level care (n=11), 7 (63.6%) were male with a median age of 71 (66.5, 76.5). 5 (45.5%) were vaccinated with three consecutive Pfizer immunizations, 4 (36.4%) received three doses of the Moderna vaccine, and 2 (18.2%) received two Janssen vaccines. 4 (36.4%) died, 3 (27.2%) were discharged to a Skilled Nursing Facility (SNF), and 2 (18.2%) were discharged home.

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    January 4, 2022: Worried about body odor? You are not alone. According to pre-COVID surveys, over one third said the fear of smelling unpleasant left them feeling unhappy and unattractive. Many people who survived COVID-19 worry about their body odor getting worse post-infection. READ MORE >>>

    January 2, 2022: Lipids play a crucial role throughout the viral life cycle, and viruses are known to exploit lipid pathways to affect host metabolism. Numerous observational studies have shown potential beneficial effects of lipid-lowering treatment on the course of COVID-19 with significant improved prognosis and reduced mortality. On the other hand, bioactive lipids have been proposed as potential drugs helping to combat COVID-19.  

    Glycerolipids and glycerophospholipids are markers of severe COVID-19, increased in ARDS (acute respiratory distress syndrome). Lipid storm can be self-destructive enhancing peptide-mediated cytokine storms. Dysregulation of lipid metabolism may be a defining feature of the severity of COVID-19. 
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    January 1, 2022:

    All living beings are constantly adapting and evolving in many different ways. Genetic evolution happens because mutations - wrong building blocks of DNA - are randomly introduced during the copying and repair of genetic material. Not all mutations are meaningful, but those that affect cellular processes or lead to amino acid changes, can change the organism’s fitness - the ability to replicate and transmit and strive in different environments. Evolution can also happen through recombination. It is much faster than one nucleotide at a time and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - first identified in 2019 - is especially good in using this mechanism.  READ MORE >>>

    As Coronavirus is evolving breakthrough infections are not breakthroughs anymore. 

    The first Israeli who died from Omicron was a fully vaccinated and boosted woman. The first Australian was a fully vaccinated man in his 80s with an underlying health condition. The first US case was a reinfection in an unvaccinated man in his 50s.

    According to today's technical briefing from UK Health Security Agency, a total of 57 people has been reported to have died within 28 days of an Omicron COVID-19 diagnosis up to 29 December 2021. The median time from Omicron specimen date to death was 5 days (range 0 to 14). The age of those dying ranged from 41 to 99 years.

    23% of Omicron cases were vaccinated with 3 doses, over 50% with two doses, while 25% where not vaccinated at all. No information about vaccination status of most Omicron deaths is available yet. READ MORE >>>