• NCT04832932
  • NCT03451994
  • NCT03582826
  • NCT02692495
  • NCT02683876

    Conquering COVID

  • Autoimmunity: 5/16/2021
  • Anaphylaxis: 3/20/2021
  • Genes and Proteins: 4/13/2020
  • Personalized vaccines: 5/21/2020

    Other Blog Posts

  • Personalized vaccines

        May 21, 2020   

    Could the development of novel vaccine candidates be better directed and predicted based on the genetic history of an individual and/or a genetically similar sub-population?

    Until the late 1990s, vaccines were developed by an empirical method based on the “Isolate–Inactivate–Inject” paradigm.  Traditional vaccinology relied on empirical screening of a few candidates at a time - a weakened or inactivated virus particle or a microbial party - such as a viral spike protein responsible for penetrating inside the cell or a bacterial toxin.

    But vaccines are amenable to and should be personalized, based on results of high throughput “omics” technologies-based diagnostics. 

    Vaccines ability to provide immunity depends on polymorphisms in genes influencing/regulating infection process or immune response. Next-generation high throughput sequencing technologies (NGS) that became available at the onset of this century enabled identification of mutations targetable by individualized vaccines. Improvements in mRNA delivery had a major impact on mRNA therapeutics and the development of new cancer vaccines.

    ... Read more ...

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    January 20, 2021: Irritable Bowel and COVID-19 : Abdominal pain is less widely known as a symptom of COVID-19, yet it is  - along with shortness of breath and confusion - a potential sign of the most severe form of COVID-19. In children, having gastrointestinal symptoms was more frequently associated with severe and critical phenotype.
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