Among genes responsible for blood type, the ABO gene is one of the most important. This gene comes in 3 different flavors responsible for sugars sprinkled on red blood cells that help fight infection.
Blood group types are associated with higher or lower susceptibility to many diseases and conditions. Blood group A, for example, may predispose to severe malaria, while blood O protects against it. Persons with blood group type AB were less affected by the norovirus infection in the 2003 Japanese outbreak. Blood group type B are twice more susceptible to group B streptococcal disease.
Blood group types also influence bacteria in our gut. One study showed that the presence of blood group A antigens was associated with lower prevalence of the genus Blautia and that this reduction is accompanied by higher abundances of Rikenellaceae, Peptostreptococcaceae, Clostridiales, and Turicibacter.
Could blood group types also make people more susceptible to developing
The most common blood type in the world is O+ (~36.4%). About 4.3% have blood type O-. Blood types A+, B+ and AB+ are prevalent at approximately 28.3%, 20.6% and 5.1% respectively. Percentages for A-, B- and AB- are 3.5%, 1.4% and 0.5%.
These percentages may differ by country, but it appears that A- and B- blood types are less prevalent in MEBO population, while O and AB are more common.
Symptom-less diet was also different for different blood group types. Average Quality of Life score was 83, 92, 95 and 91 for O, A, B and AB groups, respectively (best for B, then A, worst for O), while MEBO symptoms were also least severe and most controllable for B- type, but worse for those with A antigens.
The widest variation in MEBO symptoms was in the AB group.
We'll talk about this and other insights in more detail in our following posts.
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Update on Clinical trial NCT03582826: Microbial Basis of Systemic Malodor and PATM Conditions
Recruited: 110 participants, Distributed 330 kits, Received IDs for 141 kits
Completed study: 40 participants
Submitted 2 samples: 6
Submitted 1 sample: 9
Answered questionnaire, received kits, but did not submit/share kit numbers: 7
Did not return samples nor
answered QoL questionnaire: 48 participants
Status of data analysis: awaiting on results from uBiome.